Gene: LRRFIP2

Alternate names for this Gene: HUFI-2

Gene Summary: The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex.

Gene is located in Chromosome: 3

Location in Chromosome : 3p22.2

Description of this Gene: LRR binding FLII interacting protein 2

Type of Gene: protein-coding