Gene: LRRK1

Alternate names for this Gene: RIPK6|Roco1

Gene Summary: This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption.

Gene is located in Chromosome: 15

Location in Chromosome : 15q26.3

Description of this Gene: leucine rich repeat kinase 1

Type of Gene: protein-coding

rs11247252 in LRRK1 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs930847 in LRRK1 gene and Central corneal thickness PMID 29760442 2018 Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.

rs930847 in LRRK1 gene and Corneal Topography PMID 23291589 2013 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.