Gene: LRRK2

Alternate names for this Gene: AURA17|DARDARIN|PARK8|RIPK7|ROCO2

Gene Summary: This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.

Gene is located in Chromosome: 12

Location in Chromosome : 12q12

Description of this Gene: leucine rich repeat kinase 2

Type of Gene: protein-coding

Gene: LRRK2-DT

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Gene: LINC02471

Alternate names for this Gene: -

Gene Summary:

Gene is located in Chromosome: 12

Location in Chromosome : 12q12

Description of this Gene: long intergenic non-protein coding RNA 2471

Type of Gene: ncRNA

Gene: LOC105369735

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rs11175593 in LRRK2;LRRK2-DT;LINC02471;LOC105369735 gene and Asthma PMID 21150878 2011 Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia.

rs11175593 in LRRK2;LRRK2-DT;LINC02471;LOC105369735 gene and Crohn Disease PMID 18587394 2008 Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

rs11175593 in LRRK2;LRRK2-DT;LINC02471;LOC105369735 gene and Multiple Sclerosis PMID 22190364 2011 Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.