Gene: LRRK2

Alternate names for this Gene: AURA17|DARDARIN|PARK8|RIPK7|ROCO2

Gene Summary: This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.

Gene is located in Chromosome: 12

Location in Chromosome : 12q12

Description of this Gene: leucine rich repeat kinase 2

Type of Gene: protein-coding

Gene: LRRK2-DT

Alternate names for this Gene:

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rs1907631 in LRRK2;LRRK2-DT gene and Low density lipoprotein cholesterol measurement PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.

rs76904798 in LRRK2;LRRK2-DT gene and Parkinson Disease PMID 28892059 2017 A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci.

PMID 25064009 2014 Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.

rs1907631 in LRRK2;LRRK2-DT gene and Serum total cholesterol measurement PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.