Gene: MAGED1

Alternate names for this Gene: DLXIN-1|NRAGE

Gene Summary: This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene.

Gene is located in Chromosome: X

Location in Chromosome : Xp11.22

Description of this Gene: MAGE family member D1

Type of Gene: protein-coding

rs5991735 in MAGED1 gene and Malignant neoplasm of prostate PMID 18264097 2008 Multiple newly identified loci associated with prostate cancer susceptibility.