Gene: MALRD1

Alternate names for this Gene: C10orf112|DIET1|bA265G8.2

Gene Summary: This gene encodes a conserved protein that features multiple MAM (meprin-A5-protein tyrosine phosphatase mu) and LDLR A2 (low density lipoprotein receptor A2) domains. Expression of this gene is enriched in the small intestine and is upregulated during differentiation of a human cell line that exhibits properties of intestinal epithelial cells. The encoded protein has been shown to modulate production of FGF19 in a human intestinal cell line and may regulate bile acid metabolism in the liver. A synergistic interaction between an allele of this gene and the APOE E4 allele is associated with an elevated risk of Alzheimer's disease in human patients.

Gene is located in Chromosome: 10

Location in Chromosome : 10p12.31

Description of this Gene: MAM and LDL receptor class A domain containing 1

Type of Gene: protein-coding

rs7099812 in MALRD1 gene and Alopecia Areata PMID 22027810 2012 Genome-wide pooling approach identifies SPATA5 as a new susceptibility locus for alopecia areata.

rs10764094 in MALRD1 gene and Aortic Stiffness PMID 22068335 2012 Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium.

rs11011369 in MALRD1 gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs11008347 in MALRD1 gene and Carcinoma of lung PMID 29924316 2018 Genome-wide association study of familial lung cancer.

rs1326986 in MALRD1 gene and Smoking Behaviors PMID 20418888 2010 Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.