Gene: MAP2K5

Alternate names for this Gene: HsT17454|MAPKK5|MEK5|PRKMK5

Gene Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.

Gene is located in Chromosome: 15

Location in Chromosome : 15q23

Description of this Gene: mitogen-activated protein kinase kinase 5

Type of Gene: protein-coding

Gene: LOC107984718

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rs997295 in MAP2K5;LOC107984718 gene and Body mass index procedure PMID 23001569 2013 Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals.

rs997295 in MAP2K5;LOC107984718 gene and Finding of body mass index PMID 23001569 2013 Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals.

rs997295 in MAP2K5;LOC107984718 gene and Motion Sickness PMID 25628336 2015 Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.