Gene: MAP4K4

Alternate names for this Gene: FLH21957|HEL-S-31|HGK|MEKKK4|NIK

Gene Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene is located in Chromosome: 2

Location in Chromosome : 2q11.2

Description of this Gene: mitogen-activated protein kinase kinase kinase kinase 4

Type of Gene: protein-coding

rs12468899 in MAP4K4 gene and Asthma PMID 27130862 2016 Identification of a new locus at 16q12 associated with time to asthma onset.

rs6650791 in MAP4K4 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs111955202 in MAP4K4 gene and Eosinophil count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs34043159 in MAP4K4 gene and Parkinson Disease PMID 28892059 2017 A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci.

rs6543087 in MAP4K4 gene and White Blood Cell Count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.