Gene: MAPK10

Alternate names for this Gene: JNK3|JNK3A|PRKM10|SAPK1b|p493F12|p54bSAPK

Gene Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.

Gene is located in Chromosome: 4

Location in Chromosome : 4q21.3

Description of this Gene: mitogen-activated protein kinase 10

Type of Gene: protein-coding