Gene: MAPK12

Alternate names for this Gene: ERK-6|ERK3|ERK6|MAPK 12|P38GAMMA|PRKM12|SAPK-3|SAPK3

Gene Summary: Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.

Gene is located in Chromosome: 22

Location in Chromosome : 22q13.33

Description of this Gene: mitogen-activated protein kinase 12

Type of Gene: protein-coding

Gene: HDAC10

Alternate names for this Gene: HD10

Gene Summary: The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 22

Location in Chromosome : 22q13.33

Description of this Gene: histone deacetylase 10

Type of Gene: protein-coding

rs4838866 in MAPK12;HDAC10 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.