Gene: MAPKAP1

Alternate names for this Gene: JC310|MIP1|SIN1|SIN1b|SIN1g

Gene Summary: This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.

Gene is located in Chromosome: 9

Location in Chromosome : 9q33.3

Description of this Gene: MAPK associated protein 1

Type of Gene: protein-coding

rs2416963 in MAPKAP1 gene and Duration of sleep PMID 30531941 2018 GWAS identifies 14 loci for device-measured physical activity and sleep duration.

rs41305447 in MAPKAP1 gene and Intelligence PMID 29844566 2018 Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

rs490234 in MAPKAP1 gene and Mean blood pressure PMID 26390057 2015 Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.

rs10986769 in MAPKAP1 gene and Myocardial Infarction PMID 21211798 2011 Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations.

rs10739663 in MAPKAP1 gene and RESTING HEART RATE PMID 27798624 2016 Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.

rs7852065 in MAPKAP1 gene and Systolic Pressure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.