Gene: MCL1

Alternate names for this Gene: BCL2L3|EAT|MCL1-ES|MCL1L|MCL1S|Mcl-1|TM|bcl2-L-3|mcl1/EAT

Gene Summary: This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.

Gene is located in Chromosome: 1

Location in Chromosome : 1q21.2

Description of this Gene: MCL1 apoptosis regulator, BCL2 family member

Type of Gene: protein-coding

Gene: ADAMTSL4-AS1

Alternate names for this Gene: C1orf138

Gene Summary:

Gene is located in Chromosome: 1

Location in Chromosome : 1q21.2

Description of this Gene: ADAMTSL4 antisense RNA 1

Type of Gene: ncRNA

rs878471 in MCL1;ADAMTSL4-AS1 gene and Forced expiratory volume function PMID 30804560 2019 New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

rs878471 in MCL1;ADAMTSL4-AS1 gene and Vital capacity PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 30804560 2019 New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.