Gene: ME2

Alternate names for this Gene: ODS1

Gene Summary: This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene.

Gene is located in Chromosome: 18

Location in Chromosome : 18q21.2

Description of this Gene: malic enzyme 2

Type of Gene: protein-coding