Gene: MECOM-AS1

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: MECOM

Alternate names for this Gene: AML1-EVI-1|EVI1|KMT8E|MDS1|MDS1-EVI1|PRDM3|RUSAT2

Gene Summary: The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.

Gene is located in Chromosome: 3

Location in Chromosome : 3q26.2

Description of this Gene: MDS1 and EVI1 complex locus

Type of Gene: protein-coding

rs1918973 in MECOM-AS1;MECOM gene and Alcohol consumption PMID 29912962 2018 Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

rs73174306 in MECOM-AS1;MECOM gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs1918974 in MECOM-AS1;MECOM gene and Coronary heart disease PMID 21347282 2011 Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.

rs1918974 in MECOM-AS1;MECOM gene and Diastolic blood pressure PMID 19430483 2009 Genome-wide association study identifies eight loci associated with blood pressure.

rs1918974 in MECOM-AS1;MECOM gene and Diastolic blood pressure measurement PMID 19430483 2009 Genome-wide association study identifies eight loci associated with blood pressure.

rs1918976 in MECOM-AS1;MECOM gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs1918973 in MECOM-AS1;MECOM gene and Mean blood pressure PMID 29912962 2018 Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.