Gene: MED13

Alternate names for this Gene: ARC250|DRIP250|HSPC221|MRD61|THRAP1|TRAP240

Gene Summary: This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator.

Gene is located in Chromosome: 17

Location in Chromosome : 17q23.2

Description of this Gene: mediator complex subunit 13

Type of Gene: protein-coding