Gene: MED24

Alternate names for this Gene: ARC100|CRSP100|CRSP4|DRIP100|MED5|THRAP4|TRAP100

Gene Summary: This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 17

Location in Chromosome : 17q21.1

Description of this Gene: mediator complex subunit 24

Type of Gene: protein-coding

rs11078936 in MED24 gene and Asthma PMID 20860503 2010 A large-scale, consortium-based genomewide association study of asthma.

rs143199581 in MED24 gene and Glomerular Filtration Rate PMID 31152163 2019 A catalog of genetic loci associated with kidney function from analyses of a million individuals.

rs2302777 in MED24 gene and Multiple Myeloma PMID 23502783 2013 The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.

rs12453732 in MED24 gene and Neutrophil count (procedure) PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

rs2227336 in MED24 gene and White Blood Cell Count procedure PMID 28158719 2017 Genome-wide association of white blood cell counts in Hispanic/Latino Americans: the Hispanic Community Health Study/Study of Latinos.