Gene: MFSD13A

Alternate names for this Gene: C10orf77|TMEM180|bA18I14.8

Gene Summary:

Gene is located in Chromosome: 10

Location in Chromosome : 10q24.32

Description of this Gene: major facilitator superfamily domain containing 13A

Type of Gene: protein-coding

Gene: ACTR1A

Alternate names for this Gene: ARP1|Arp1A|CTRN1

Gene Summary: This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin.

Gene is located in Chromosome: 10

Location in Chromosome : 10q24.32

Description of this Gene: actin related protein 1A

Type of Gene: protein-coding

rs10883723 in MFSD13A;ACTR1A gene and Allergic Reaction PMID 29083406 2017 Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.

rs35597970 in MFSD13A;ACTR1A gene and Allergic rhinitis (disorder) PMID 30013184 2018 Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.