Gene: MIAT
Alternate names for this Gene: C22orf35|GOMAFU|LINC00066|NCRNA00066|RNCR2|lncRNA-MIAT
Gene Summary: This gene encodes a spliced long non-coding RNA that may constitute a component of the nuclear matrix. Altered expression of this locus has been reported to be associated with a susceptibility to myocardial infarction. It has also been proposed that pathways involving this transcript may contribute to the pathophysiology of schizophrenia. A similar gene in mouse has been associated with retinal cell fate determination. Alternatively spliced transcript variants have been identified.
Gene is located in Chromosome: 22
Location in Chromosome : 22q12.1
Description of this Gene: myocardial infarction associated transcript
Type of Gene: ncRNA
rs2331291 in
MIAT gene and
Myocardial Infarction
PMID 17066261 2006 Following linkage disequilibrium (LD) mapping, haplotype analyses revealed that six SNPs in this locus, all of which were in complete LD, showed markedly significant association with MI (chi2=25.27, P=0.0000005; comparison of allele frequency, 3,435 affected individuals versus 3,774 controls, in the case of intron 1 5,338 C>T; rs2331291).