Gene: MICB

Alternate names for this Gene: PERB11.2

Gene Summary: This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.33

Description of this Gene: MHC class I polypeptide-related sequence B

Type of Gene: protein-coding

Gene: MICB-DT

Alternate names for this Gene: TCONS_00012692

Gene Summary:

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.33

Description of this Gene: MICB divergent transcript

Type of Gene: ncRNA

rs2534678 in MICB;MICB-DT gene and ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO PMID 20041166 2009 Common genetic variation and the control of HIV-1 in humans.

rs2534678 in MICB;MICB-DT gene and AIDS, PROGRESSION TO PMID 20041166 2009 Common genetic variation and the control of HIV-1 in humans.

rs2534678 in MICB;MICB-DT gene and Diabetes Mellitus, Insulin-Dependent PMID 17632545 2007 A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.

rs2534678 in MICB;MICB-DT gene and HIV-1, RESISTANCE TO PMID 20041166 2009 Common genetic variation and the control of HIV-1 in humans.

rs2534678 in MICB;MICB-DT gene and HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO PMID 20041166 2009 Common genetic variation and the control of HIV-1 in humans.