Gene: MIR4435-2HG

Alternate names for this Gene: AGD2|LINC00978|MIR4435-1HG|MORRBID|lncRNA-AWPPH

Gene Summary:

Gene is located in Chromosome: 2

Location in Chromosome : 2q13

Description of this Gene: MIR4435-2 host gene

Type of Gene: ncRNA

Gene: BCL2L11

Alternate names for this Gene: BAM|BIM|BOD

Gene Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

Gene is located in Chromosome: 2

Location in Chromosome : 2q13

Description of this Gene: BCL2 like 11

Type of Gene: protein-coding

rs71801447 in MIR4435-2HG;BCL2L11 gene and Breast Carcinoma PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.

rs6734942 in MIR4435-2HG;BCL2L11 gene and Monocyte count procedure PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs6734942 in MIR4435-2HG;BCL2L11 gene and Monocyte count result PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs11691517 in MIR4435-2HG;BCL2L11 gene and Prostate carcinoma PMID 29892016 2018 Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.