Gene: MORC4

Alternate names for this Gene: ZCW4|ZCWCC2|dJ75H8.2

Gene Summary: In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript variants encoding distinct proteins.

Gene is located in Chromosome: X

Location in Chromosome : Xq22.3

Description of this Gene: MORC family CW-type zinc finger 4

Type of Gene: protein-coding

Gene: RIPPLY1

Alternate names for this Gene: -

Gene Summary: This gene encodes a protein similar to a zebrafish protein which acts as a transcriptional repressor in and is required for somite segmentation in zebrafish embryos (PMID: 16326386). Multiple transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: X

Location in Chromosome : Xq22.3

Description of this Gene: ripply transcriptional repressor 1

Type of Gene: protein-coding

Gene: CLDN2

Alternate names for this Gene: -

Gene Summary: This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.

Gene is located in Chromosome: X

Location in Chromosome : Xq22.3

Description of this Gene: claudin 2

Type of Gene: protein-coding

rs7057398 in MORC4;RIPPLY1;CLDN2 gene and Pancreatitis PMID 23143602 2012 Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.

rs7057398 in MORC4;RIPPLY1;CLDN2 gene and Pancreatitis, Alcoholic PMID 28754779 2018 Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.