Gene: MORC4

Alternate names for this Gene: ZCW4|ZCWCC2|dJ75H8.2

Gene Summary: In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript variants encoding distinct proteins.

Gene is located in Chromosome: X

Location in Chromosome : Xq22.3

Description of this Gene: MORC family CW-type zinc finger 4

Type of Gene: protein-coding

rs12014762 in MORC4 gene and Pancreatitis PMID 23143602 2012 Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.

rs11092578 in MORC4 gene and Pancreatitis, Alcoholic PMID 28754779 2018 Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.