Gene: MRPL37

Alternate names for this Gene: L2mt|L37mt|MRP-L2|MRP-L37|MRPL2|RPML2

Gene Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.

Gene is located in Chromosome: 1

Location in Chromosome : 1p32.3

Description of this Gene: mitochondrial ribosomal protein L37

Type of Gene: protein-coding

rs1890566 in MRPL37 gene and Migraine Disorders PMID 23793025 2013 Genome-wide meta-analysis identifies new susceptibility loci for migraine.