Gene: MSH5-SAPCD1

Alternate names for this Gene: MSH5-C6orf26

Gene Summary: This locus represents naturally occurring read-through transcription between the neighboring mutS homolog 5 (MSH5) and chromosome 6 open reading frame 26 (C6orf26) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.33

Description of this Gene: MSH5-SAPCD1 readthrough (NMD candidate)

Type of Gene: ncRNA

Gene: LOC105375020

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: CLIC1

Alternate names for this Gene: CL1C1|CLCNL1|G6|NCC27

Gene Summary: Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.33

Description of this Gene: chloride intracellular channel 1

Type of Gene: protein-coding

Gene: MSH5

Alternate names for this Gene: G7|MUTSH5|NG23|POF13

Gene Summary: This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.33

Description of this Gene: mutS homolog 5

Type of Gene: protein-coding

rs3101018 in MSH5-SAPCD1;LOC105375020;CLIC1;MSH5 gene and Rheumatoid Arthritis PMID 21156761 2011 A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.