Gene: MST1R

Alternate names for this Gene: CD136|CDw136|NPCA3|PTK8|RON|SEA

Gene Summary: This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.

Gene is located in Chromosome: 3

Location in Chromosome : 3p21.31

Description of this Gene: macrophage stimulating 1 receptor

Type of Gene: protein-coding

Gene: LOC102724438

Alternate names for this Gene:

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rs2230590 in MST1R;LOC102724438 gene and Body mass index PMID 29273807 2018 Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

rs200757776 in MST1R;LOC102724438 gene and NASOPHARYNGEAL CARCINOMA, SUSCEPTIBILITY TO, 3 PMID 26951679 2016 Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma.