Gene: MT1A

Alternate names for this Gene: MT-1A|MT-IA|MT1|MT1S|MTC

Gene Summary: This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. Disruption of two metallothionein genes in mouse resulted in defects in protection against heavy metals, oxidative stress, immune reactions, carcinogens, and displayed obesity.

Gene is located in Chromosome: 16

Location in Chromosome : 16q13

Description of this Gene: metallothionein 1A

Type of Gene: protein-coding