Gene: MTRF1

Alternate names for this Gene: MRF1|MTTRF1|RF1

Gene Summary: The protein encoded by this gene was determined by in silico methods to be a mitochondrial protein with similarity to the peptide chain release factors (RFs) discovered in bacteria and yeast. The peptide chain release factors direct the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis, a recent publication found no mitochondrial translation release functionality. Multiple alternatively spliced transcript variants have been suggested by mRNA and EST data; however, their full-length natures are not clear.

Gene is located in Chromosome: 13

Location in Chromosome : 13q14.11

Description of this Gene: mitochondrial translation release factor 1

Type of Gene: protein-coding

rs112684153 in MTRF1 gene and Cardiovascular Diseases PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.