Gene: MTUS1

Alternate names for this Gene: ATBP|ATIP|ATIP3|ICIS|MP44|MTSG1

Gene Summary: This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.

Gene is located in Chromosome: 8

Location in Chromosome : 8p22

Description of this Gene: microtubule associated scaffold protein 1

Type of Gene: protein-coding

rs567116808 in MTUS1 gene and Liver carcinoma PMID 16650523 2006 Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma.