Gene: MX2

Alternate names for this Gene: MXB

Gene Summary: The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1.

Gene is located in Chromosome: 21

Location in Chromosome : 21q22.3

Description of this Gene: MX dynamin like GTPase 2

Type of Gene: protein-coding

rs416981 in MX2 gene and Cutaneous Melanoma PMID 30429480 2018 Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.

rs416981 in MX2 gene and Malignant melanoma of skin of lower limb PMID 30429480 2018 Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.

rs416981 in MX2 gene and Malignant melanoma of skin of upper limb PMID 30429480 2018 Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.

rs78736162 in MX2 gene and Parkinson Disease PMID 25663231 2015 PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease.

rs45430 in MX2 gene and melanoma PMID 28212542 2017 Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma.

PMID 21983787 2011 Genome-wide association study identifies three new melanoma susceptibility loci.