Gene: MYRF

Alternate names for this Gene: 11orf9|C11orf9|CUGS|MMERV|MRF|Ndt80|pqn-47

Gene Summary: This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 11

Location in Chromosome : 11q12.2

Description of this Gene: myelin regulatory factor

Type of Gene: protein-coding

Gene: MYRF-AS1

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rs198462 in MYRF;MYRF-AS1 gene and Phospholipid measurement PMID 21829377 2011 Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.

rs198421 in MYRF;MYRF-AS1 gene and Serum albumin measurement PMID 22286219 2012 Genome-wide association study identifies multiple loci influencing human serum metabolite levels.