Gene: NAALAD2

Alternate names for this Gene: GCPIII|GPCIII|NAADALASE2|NAALADASE2

Gene Summary: This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. Two transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 11

Location in Chromosome : 11q14.3

Description of this Gene: N-acetylated alpha-linked acidic dipeptidase 2

Type of Gene: protein-coding

rs11018874 in NAALAD2 gene and Blood basophil count (lab test) PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

PMID 21738478 2011 Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.

rs61903695 in NAALAD2 gene and Body mass index PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

rs11018874 in NAALAD2 gene and Eosinophil count procedure PMID 21738478 2011 Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.

rs11018904 in NAALAD2 gene and Intelligence PMID 29326435 2019 A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.