Gene: NAPB

Alternate names for this Gene: SNAP-BETA|SNAPB

Gene Summary: This gene encodes a member of the soluble N-ethyl-maleimide-sensitive fusion attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. This gene encodes the SNAP beta isoform which has been shown to be preferentially expressed in brain tissue. The encoded protein also interacts with the GluR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit C-terminus and may play a role as a chaperone in the molecular processing of the AMPA receptor.

Gene is located in Chromosome: 20

Location in Chromosome : 20p11.21

Description of this Gene: NSF attachment protein beta

Type of Gene: protein-coding

rs6083120 in NAPB gene and Factor VII measurement PMID 30642921 2019 A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology.