Gene: NCF4

Alternate names for this Gene: CGD3|NCF|P40PHOX|SH3PXD4

Gene Summary: The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene is located in Chromosome: 22

Location in Chromosome : 22q12.3

Description of this Gene: neutrophil cytosolic factor 4

Type of Gene: protein-coding

Gene: NCF4-AS1

Alternate names for this Gene: -

Gene Summary:

Gene is located in Chromosome: 22

Location in Chromosome : 22q12.3

Description of this Gene: NCF4 antisense RNA 1

Type of Gene: ncRNA