Gene: NCK1

Alternate names for this Gene: NCK|NCKalpha|nck-1

Gene Summary: The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.

Gene is located in Chromosome: 3

Location in Chromosome : 3q22.3

Description of this Gene: NCK adaptor protein 1

Type of Gene: protein-coding

rs9879531 in NCK1 gene and Blood urea nitrogen measurement PMID 31152163 2019 A catalog of genetic loci associated with kidney function from analyses of a million individuals.

rs11715604 in NCK1 gene and Chronic Lymphocytic Leukemia PMID 28112199 2017 Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.

rs11715604 in NCK1 gene and Hodgkin Disease PMID 28112199 2017 Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.

rs11715604 in NCK1 gene and Multiple Myeloma PMID 28112199 2017 Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.

rs11715604 in NCK1 gene and Small Lymphocytic Lymphoma PMID 28112199 2017 Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.

rs6800032 in NCK1 gene and White Blood Cell Count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.