Gene: NCKIPSD

Alternate names for this Gene: AF3P21|DIP|DIP1|ORF1|SPIN90|VIP54|WASLBP|WISH

Gene Summary: The protein encoded by this gene contains a nuclear localization signal. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation This protein is involved in the formation and maintenance of dendritic spines, and modulates synaptic activity in neurons. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing results in multiple transcript variants of this gene.

Gene is located in Chromosome: 3

Location in Chromosome : 3p21.31

Description of this Gene: NCK interacting protein with SH3 domain

Type of Gene: protein-coding

rs9821797 in NCKIPSD gene and Anorexia Nervosa PMID 31308545 2019 Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.

rs990211 in NCKIPSD gene and Eosinophil count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs73078367 in NCKIPSD gene and Intelligence PMID 29942086 2018 Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.

PMID 29326435 2019 A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.

rs75654367 in NCKIPSD gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.