Gene: NCOA1

Alternate names for this Gene: F-SRC-1|KAT13A|RIP160|SRC1|bHLHe42|bHLHe74

Gene Summary: The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene is located in Chromosome: 2

Location in Chromosome : 2p23.3

Description of this Gene: nuclear receptor coactivator 1

Type of Gene: protein-coding

rs10865308 in NCOA1 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs2044148 in NCOA1 gene and Body mass index PMID 30108127 2018 A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.

rs200648189 in NCOA1 gene and Breast Carcinoma PMID 29058716 2017 Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

rs55783347 in NCOA1 gene and Intelligence PMID 28093568 2017 GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium.

rs2044148 in NCOA1 gene and Physical Activity Measurement PMID 28448500 2017 Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

rs6545667 in NCOA1 gene and Triglycerides measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.