Gene: NCOA5

Alternate names for this Gene: CIA|bA465L10.6

Gene Summary: This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene.

Gene is located in Chromosome: 20

Location in Chromosome : 20q13.12

Description of this Gene: nuclear receptor coactivator 5

Type of Gene: protein-coding

rs17450969 in NCOA5 gene and Adiponectin Measurement PMID 20887962 2010 Adiponectin concentrations: a genome-wide association study.

rs2425752 in NCOA5 gene and Diffuse Large B-Cell Lymphoma PMID 31407831 2019 Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.

rs2425752 in NCOA5 gene and Hodgkin Disease PMID 30194254 2018 We identify 5 new HL risk loci at 6p21.31 (rs649775; <i>P</i> = 2.11 × 10<sup>-10</sup>), 6q23.3 (rs1002658; <i>P</i> = 2.97 × 10<sup>-8</sup>), 11q23.1 (rs7111520; <i>P</i> = 1.44 × 10<sup>-11</sup>), 16p11.2 (rs6565176; <i>P</i> = 4.00 × 10<sup>-8</sup>), and 20q13.12 (rs2425752; <i>P</i> = 2.01 × 10<sup>-8</sup>).

rs6074013 in NCOA5 gene and Major Depressive Disorder PMID 29942085 2018 Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.

rs2425752 in NCOA5 gene and Marginal Zone B-Cell Lymphoma PMID 31407831 2019 Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.

rs6074013 in NCOA5 gene and Mood Disorders PMID 29942085 2018 Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.

rs2425752 in NCOA5 gene and Multiple Sclerosis PMID 21833088 2011 Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

PMID 31407831 2019 Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.

rs6074015 in NCOA5 gene and Red Blood Cell Count measurement PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.