Gene: NEDD4
Alternate names for this Gene: NEDD4-1|RPF1
Gene Summary: This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN.
Gene is located in Chromosome: 15
Location in Chromosome : 15q21.3
Description of this Gene: NEDD4 E3 ubiquitin protein ligase
Type of Gene: protein-coding