Gene: NEDD9

Alternate names for this Gene: CAS-L|CAS2|CASL|CASS2|HEF1

Gene Summary: The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 6

Location in Chromosome : 6p24.2

Description of this Gene: neural precursor cell expressed, developmentally down-regulated 9

Type of Gene: protein-coding

rs7738851 in NEDD9 gene and Dental caries PMID 29931343 2018 Evidence for association with caries status was observed at rs1594318-C for primary teeth [intronic within ALLC, odds ratio (OR) 0.85, effect allele frequency (EAF) 0.60, P 4.13e-8] and rs7738851-A (intronic within NEDD9, OR 1.28, EAF 0.85, P 1.63e-8) for permanent teeth.

rs11961171 in NEDD9 gene and Glaucoma, Open-Angle PMID 22605921 2012 Genome-wide association study of primary open angle glaucoma risk and quantitative traits.

rs4713266 in NEDD9 gene and Prostate carcinoma PMID 29892016 2018 Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

PMID 25217961 2014 A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.