Gene: NEXN

Alternate names for this Gene: CMH20|NELIN

Gene Summary: This gene encodes a filamentous actin-binding protein that may function in cell adhesion and migration. Mutations in this gene have been associated with dilated cardiomyopathy, also known as CMD1CC. Alternatively spliced transcript variants have been described.

Gene is located in Chromosome: 1

Location in Chromosome : 1p31.1

Description of this Gene: nexilin F-actin binding protein

Type of Gene: protein-coding

rs146245480 in NEXN gene and CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 20 PMID 20970104 2010 Mutations in NEXN, a Z-disc gene, are associated with hypertrophic cardiomyopathy.

rs137853197 in NEXN gene and Cardiomyopathy, Dilated PMID 19881492 2009 Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy.

rs137853197 in NEXN gene and Cardiomyopathy, Dilated, 1CC PMID 19881492 2009 Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy.

rs9661687 in NEXN gene and Forced expiratory volume function PMID 30804560 2019 New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

rs9661687 in NEXN gene and peak expiratory flow (procedure) PMID 30804560 2019 New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.