Gene: NFS1

Alternate names for this Gene: HUSSY-08|IscS|NIFS

Gene Summary: Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described.

Gene is located in Chromosome: 20

Location in Chromosome : 20q11.22

Description of this Gene: NFS1 cysteine desulfurase

Type of Gene: protein-coding

Gene: ROMO1

Alternate names for this Gene: C20orf52|MTGM|MTGMP|bA353C18.2

Gene Summary: The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial membrane breakage.

Gene is located in Chromosome: 20

Location in Chromosome : 20q11.22

Description of this Gene: reactive oxygen species modulator 1

Type of Gene: protein-coding

Gene: RBM39

Alternate names for this Gene: CAPER|CAPERalpha|FSAP59|HCC1|RNPC2

Gene Summary: This gene encodes a member of the U2AF65 family of proteins. The encoded protein is found in the nucleus, where it co-localizes with core spliceosomal proteins. It has been shown to play a role in both steroid hormone receptor-mediated transcription and alternative splicing, and it is also a transcriptional coregulator of the viral oncoprotein v-Rel. Multiple transcript variants have been observed for this gene. A related pseudogene has been identified on chromosome X.

Gene is located in Chromosome: 20

Location in Chromosome : 20q11.22

Description of this Gene: RNA binding motif protein 39

Type of Gene: protein-coding

rs3088078 in NFS1;ROMO1;RBM39 gene and Protein C antigen measurement PMID 20802025 2010 Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study.

rs3088078 in NFS1;ROMO1;RBM39 gene and Protein C measurement PMID 20802025 2010 Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study.