Gene: NFX1

Alternate names for this Gene: NFX2|TEG-42|Tex42

Gene Summary: MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.

Gene is located in Chromosome: 9

Location in Chromosome : 9p13.3

Description of this Gene: nuclear transcription factor, X-box binding 1

Type of Gene: protein-coding