Gene: NFYA

Alternate names for this Gene: CBF-A|CBF-B|HAP2|NF-YA

Gene Summary: The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.1

Description of this Gene: nuclear transcription factor Y subunit alpha

Type of Gene: protein-coding

Gene: OARD1

Alternate names for this Gene: C6orf130|TARG1|dJ34B21.3

Gene Summary: The protein encoded by this gene is a deacylase that can convert O-acetyl-ADP-ribose to ADP-ribose and acetate, O-propionyl-ADP-ribose to ADP-ribose and propionate, and O-butyryl-ADP-ribose to ADP-ribose and butyrate. The ADP-ribose product is able to inhibit these reactions through a competitive feedback loop.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.1

Description of this Gene: O-acyl-ADP-ribose deacylase 1

Type of Gene: protein-coding