Gene: NOSIP
Alternate names for this Gene: CGI-25
Gene Summary: The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein.
Gene is located in Chromosome: 19
Location in Chromosome : 19q13.33
Description of this Gene: nitric oxide synthase interacting protein
Type of Gene: protein-coding
Gene: PRRG2
Alternate names for this Gene: PRGP2
Gene Summary: The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene.
Gene is located in Chromosome: 19
Location in Chromosome : 19q13.33
Description of this Gene: proline rich and Gla domain 2
Type of Gene: protein-coding
rs56873913 in
NOSIP;PRRG2 gene and
Schizophrenia
PMID 31268507 2019 Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study.
PMID 30285260 2019 Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.
PMID 28991256 2017 Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia.
PMID 26198764 2015 Genome-wide association study of schizophrenia in Ashkenazi Jews.
PMID 25056061 2014 Biological insights from 108 schizophrenia-associated genetic loci.