Gene: NTAN1

Alternate names for this Gene: PNAA|PNAD

Gene Summary: The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Gene is located in Chromosome: 16

Location in Chromosome : 16p13.11

Description of this Gene: N-terminal asparagine amidase

Type of Gene: protein-coding

Gene: PDXDC1

Alternate names for this Gene: LP8165

Gene Summary:

Gene is located in Chromosome: 16

Location in Chromosome : 16p13.11

Description of this Gene: pyridoxal dependent decarboxylase domain containing 1

Type of Gene: protein-coding

rs3803573 in NTAN1;PDXDC1 gene and Lean body mass PMID 30593698 2019 Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.

rs4500751 in NTAN1;PDXDC1 gene and Phospholipid measurement PMID 22359512 2012 Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.

rs34955778 in NTAN1;PDXDC1 gene and Serum albumin measurement PMID 22286219 2012 Genome-wide association study identifies multiple loci influencing human serum metabolite levels.