Gene: NXN

Alternate names for this Gene: NRX|RRS2|TRG-4

Gene Summary: This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation.

Gene is located in Chromosome: 17

Location in Chromosome : 17p13.3

Description of this Gene: nucleoredoxin

Type of Gene: protein-coding

rs12603526 in NXN gene and Adenocarcinoma of large intestine PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs4968127 in NXN gene and Adenoma of large intestine PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

rs747685 in NXN gene and Blood Pressure PMID 24954895 2014 Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.

rs12603526 in NXN gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs12603526 in NXN gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 10 PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs12603526 in NXN gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 12 PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs12603526 in NXN gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 3 PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs12603526 in NXN gene and Colorectal Carcinoma PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs12603526 in NXN gene and Colorectal Neoplasms PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs747687 in NXN gene and Diastolic blood pressure PMID 24954895 2014 Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.

rs12603526 in NXN gene and Malignant neoplasm of large intestine PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs12603526 in NXN gene and Malignant tumor of colon PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.

PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.

PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.

PMID 31089142 2019 Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

rs747685 in NXN gene and Mean blood pressure PMID 24954895 2014 Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.