Gene: OR1B1

Alternate names for this Gene: OR9-26|OR9-B

Gene Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional.

Gene is located in Chromosome: 9

Location in Chromosome : 9q33.2

Description of this Gene: olfactory receptor family 1 subfamily B member 1

Type of Gene: protein-coding

rs10985729 in OR1B1 gene and Uveal melanoma PMID 31626034 2020 Genome-wide study on uveal melanoma patients finds association to DNA repair gene TDP1.

rs10985729 in OR1B1 gene and epithelioid cell intraocular melanoma PMID 31626034 2020 Genome-wide study on uveal melanoma patients finds association to DNA repair gene TDP1.