Gene: OR2H2

Alternate names for this Gene: FAT11|OLFR2|OLFR42B|OR2H3|dJ271M21.2|hs6M1-12

Gene Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Gene is located in Chromosome: 6

Location in Chromosome : 6p22.1

Description of this Gene: olfactory receptor family 2 subfamily H member 2

Type of Gene: protein-coding

Gene: GABBR1

Alternate names for this Gene: GABABR1|GABBR1-3|GB1|GPRC3A

Gene Summary: This gene encodes a receptor for gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. This receptor functions as a heterodimer with GABA(B) receptor 2. Defects in this gene may underlie brain disorders such as schizophrenia and epilepsy. Alternative splicing generates multiple transcript variants, but the full-length nature of some of these variants has not been determined.

Gene is located in Chromosome: 6

Location in Chromosome : 6p22.1

Description of this Gene: gamma-aminobutyric acid type B receptor subunit 1

Type of Gene: protein-coding

rs1233384 in OR2H2;GABBR1 gene and Rheumatoid Arthritis PMID 19503088 2009 REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.