Gene: OR3A2

Alternate names for this Gene: OLFRA04|OR17-14|OR17-228|OR228

Gene Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Gene is located in Chromosome: 17

Location in Chromosome : 17p13.3

Description of this Gene: olfactory receptor family 3 subfamily A member 2

Type of Gene: protein-coding

rs2955821 in OR3A2 gene and Adolescent idiopathic scoliosis PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs2005290 in OR3A2 gene and Cocaine Dependence PMID 23958962 2014 Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.

rs2005290 in OR3A2 gene and Mental and behavioral disorders due to use of cocaine, unspecified mental and behavioral disorder PMID 23958962 2014 Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.

rs2955821 in OR3A2 gene and SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.