Gene: ORC4

Alternate names for this Gene: ORC4L|ORC4P

Gene Summary: The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene.

Gene is located in Chromosome: 2

Location in Chromosome : 2q23.1

Description of this Gene: origin recognition complex subunit 4

Type of Gene: protein-coding

rs11901963 in ORC4 gene and Arthritis, Gouty PMID 23263486 2013 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

rs12989250 in ORC4 gene and Glomerular Filtration Rate PMID 31152163 2019 A catalog of genetic loci associated with kidney function from analyses of a million individuals.

rs11901963 in ORC4 gene and Gout PMID 23263486 2013 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

rs1085307083 in ORC4 gene and MEIER-GORLIN SYNDROME 2 PMID 21358632 2011 Mutations in the pre-replication complex cause Meier-Gorlin syndrome.

PMID 21358631 2011 Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome.

rs2307394 in ORC4 gene and Uric acid measurement (procedure) PMID 23263486 2013 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

PMID 31578528 2019 Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.

PMID 30993211 2019 Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.